Anti-myostatin antibodies

US7632499B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Julian Davies · Village of La Jolla, US
• Bryan Edward Jones · Carmel, US
• Andrew Ihor Korytko · Oceanside, US
• Pamela Jean Mitchell · Indianapolis, US
• Rosamund Carol Smith · Greenfield, US
• Linda Maureen O'Bryan · Indianapolis, US
• Rong Wang · Mianyang, CN

Key dates

• Filing date: Oct 5, 2006
• Grant date: Dec 15, 2009
• Expiry date: Oct 8, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Anti-myostatin antibodies are identified that are characterized as having high affinity and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.