Universal carrier for targeting molecules to Gb3 receptor expressing cells

US7632514B2 · kind B2 · utility

Assignees

• INSTITUT CURIE · FR
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR
• Universite Pierre Et Marie Curie (Paris 6) · FR

Inventors

• Ludger Johannes · Courbevoie, FR
• Eric TARTOUR · Paris, FR
• Bruno Goud · Paris, FR
• Wolf Herve Fridman · Paris, FR

Key dates

• Filing date: Jul 29, 2003
• Grant date: Dec 15, 2009
• Expiry date: Jul 29, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfydryl group, n being 0, 1 or a polypeptide, Cys is the amino-acid Cysteine, and the use thereof for MHC class I and MHC class II presentation of antigens.