Bone densifying agent characterized by use of cathepsin K inhibitor with PTH
US7632813B2 · kind B2 · utility
1Cited by
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7Claims
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Key dates
| Filing date | Apr 25, 2005 |
| Grant date | Dec 15, 2009 |
| Priority date | — |
| Expiry date | Jun 20, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to an agent for increasing BMD characterized by use of a cathepsin K inhibitor as a bone resorption inhibitor in combination with a type of PTH as a bone formation stimulator. This agent for increasing BMD is useful for the treatment of osteoporosis, bone fracture, arthritis, rheumatoid arthritis, osteoarthritis, hypercalcemia, osteometastasis of carcinoma, periodontal disease, bone Paget's disease and other bone metabolic diseases. For example, as the cathepsin K inhibitor, there can be mentioned a compound of formula (W) and a salt thereof, etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.