Pyrazole compounds as HSP90 inhibitors for the treatment of cancer
US7632855B2 · kind B2 · utility
26Cited by
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20Claims
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Key dates
| Filing date | Apr 23, 2004 |
| Grant date | Dec 15, 2009 |
| Priority date | — |
| Expiry date | Dec 27, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/06191
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of formula (I) are inhibitors of HSP90 activity, and useful in the treatment of proliferative disease such as cancers: wherein R1, R2 and R3 are as defined in the specification, and X is —OR4 or —NR4R5 wherein R4 and R5 independently represent hydrogen or optionally substituted C1-C6 alkyl, or R4 and R5 taken together with the nitrogen to which they are attached form an optionally substituted nitrogen-containing ring having 5-8 ring atoms.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.