Soluble, stable form of HDM2, crystalline forms thereof and methods of use thereof
US7632920B2 · kind B2 · utility
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1References
10Claims
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Assignee
Inventors
Key dates
| Filing date | Apr 9, 2004 |
| Grant date | Dec 15, 2009 |
| Priority date | — |
| Expiry date | Apr 9, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2299/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention. The invention also provides crystals of modified Hdm2 proteins that are suitable for X-ray crystallization analysis. The present invention also discloses methods of using the modified Hdm2 proteins and crystals thereof to identify, select and/or design compounds that may be used as anticancer agents. The present invention further discloses compounds that bind to modified Hdm2 proteins in protein-ligand complexes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.