Quinolone carboxylic acids, derivatives thereof, and methods of making and using same
US7632944B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jan 24, 2007 |
| Grant date | Dec 15, 2009 |
| Priority date | — |
| Expiry date | Feb 8, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process of preparing a quinolone carboxylic acid or its derivatives having Formula I, Ia, or IV, as shown herein, comprises using a starting quinolone that already has one or more desired substituents at one or more particular positions on the quinolone ring and preserving the orientation of such substituents throughout the synthesis. The present process comprises fewer steps than prior-art processes. The present process also can include a simple separation of a desired enantiomer of the quinolone carboxylic acid or its derivatives from the enantiomeric mixture. Pharmaceutical compositions comprising fluoroquinolones prepared by the present process can be used effectively against a variety of microbial pathogens.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.