Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders

US7635472B2 · kind B2 · utility

Assignee

• Micromet AG · DE

Inventors

• Peter Kufer · Munich, DE
• Ralf Lutterbüse · Munich, DE
• Birgit Kohleisen · Munich, DE
• Steven Zeman · Zell (Mosel), DE
• Patrick Bauerle · Gauting, DE

Key dates

• Filing date: May 26, 2004
• Grant date: Dec 22, 2009
• Expiry date: Apr 23, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/622
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a pharmaceutical composition comprising a bispecific single chain antibody construct comprising binding domains specific for human CD3 and human CD19, wherein the corresponding variable heavy chain regions (VH) and the corresponding variable light chain regions (VL) regions are arranged, from N-terminus to C-terminus, in the order VH(CD19)-VL(CD19)-VH(CD3)-VL(CD3) or VH(CD3)-VL-(CD3)-VH(CD19)-VL (CD19). Processes for the production of the pharmaceutical compositions and medical/pharmaceutical uses for the specific bispecific single chain antibody molecules bearing specificities for the human CD3 antigen and the human CD19 antigen are also disclosed.