Protein crystal comprising the processivity clamp factor of DNA polymerase and a ligand, and its uses
US7635583B2 · kind B2 · utility
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Key dates
| Filing date | Jun 25, 2004 |
| Grant date | Dec 22, 2009 |
| Priority date | — |
| Expiry date | Aug 30, 2024 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A protein crystal having the processivity clamp factor of DNA polymerase that is the β subunit of DNA polymerase III of Escherichia coli and a peptide of about 3 to about 30 amino acids, in particular of about 16 amino acids. The peptide includes all or part of the processivity clamp factor binding sequence of a processivity clamp factor interacting protein, such as prokaryotic Pol I, Pol II, Pol III, Pol IV, Pol V, MutS, ligase I, α subunit of DNA polymerase, UmuD or UmuD′, or eukaryotic pol ε, pol δ, pol η, pol ι, pol κ.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.