Assays for identifying modulators of the hydroxylation of ankyrin repeat proteins by 2-oxoglutarate dependent oxygenase and methods of using the same
US7638295B2 · kind B2 · utility
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26Claims
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Key dates
| Filing date | Mar 24, 2005 |
| Grant date | Dec 29, 2009 |
| Priority date | — |
| Expiry date | Nov 7, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of identifying an agent which modulates 2-oxoglutarate dependent oxygenase activity, the method comprising contacting a 2-oxoglutarate dependent oxygenase and a test agent in the presence of a substrate comprising one or more ankyrin repeat, or fragment thereof, in conditions under which the substrate is hydroxylated in the absence of the test agent; and determining hydroxylation of the substrate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.