Method for determining co-receptor selectivity of Human Immunodeficiency Virus-1
US7638319B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 7, 2006 |
| Grant date | Dec 29, 2009 |
| Priority date | — |
| Expiry date | Mar 7, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B15/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Newly discovered structural characteristic of the gp120 V3 loop have resulted in a “rule” or algorithm, that is used in a method for determining whether a subject is infected with HIV-1 virus that expresses selectivity for CXCR4 or CCR5 chemokine receptors. A positively charged surface patch defined by V3 loop residues 11 and 24 or 25 at the base of the β-strands in the V3 loop and the homologous β2-β3 chemokine hairpin is responsible for CXCR4 receptor selection. Thus a method for detecting the presence of HIV-1 virus that is selective for X4-co-receptors in a subject infected with HIV-1 or suspected of being infected, from the amino acid sequence of at least a part of the HIV-1 gp120 V3 region peptide that includes residues 11, 24 and 25, or from the nucleotide sequence of a nucleic acid encoding said V3 region peptide, is disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.