Patent · US Active

Organophosphoric derivatives useful as anti-parasitic agents

US7638505B2 · kind B2 · utility

1Cited by

0References

19Claims

0Family size

Assignee

UNIVERSITEIT GENT · BE

Inventors

Serge Van Calenbergh · Zevergem, BE
Timothy Haemers · Mariakerke, BE
Vincent Devreux · Wervik, BE
Hassan Jomaa · Gießen, DE
Jochen Wiesner · Gießen, DE

Key dates

Filing date	Dec 22, 2006
Grant date	Dec 29, 2009
Priority date	—
Expiry date	Dec 22, 2026

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to novel phosphonic acid compounds having the structural formula (I): wherein: (a) R is a group of 1 to 5 substituents independently selected from the group consisting of fluoro, chloro, bromo, C1-4 alkoxy, C1-4 alkyl, hydroxy, formyl, trifluoromethoxy, phenyl, heterocyclic, heterocyclic-substituted methyl, aminomethyl, hydroxy methyl, bromomethyl, sulfonyl chloride, acetyl chloride, nitroso and cyano, (b) R1 is selected from the group consisting of hydrogen, C1-7 alkyl, C3-10 cycloalkyl, aryl, arylalkyl and heterocyclic, and (c) R2 is selected from the group consisting of hydroxy and hydroxy-protecting groups, and stereoisomer, solvates and salts thereof. These compounds are useful as anti-infectious and anti-parasitic agents, in particular anti-malaria agents.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.