Monoclonal antibodies against interleukin-22

US7638604B2 · kind B2 · utility

Assignee

• Genetics Institute, LLC · US

Inventors

• Jing Li · Lexington, US
• Xiang-Yang Tan · Reading, US
• Kathleen N. Tomkinson · Cambridge, US
• Debra Pittman · Windham, US
• Geertruida M. Veldman · Sudbury, US
• Lynette Fouser · Acton, US

Key dates

• Filing date: Jun 22, 2004
• Grant date: Dec 29, 2009
• Expiry date: Aug 3, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2799/022
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Antibodies and antigen-binding fragments thereof that bind interleukin-22 (IL-22), in particular, human IL-22, and their uses in regulating IL-22-associated immune responses are disclosed. The antibodies disclosed herein are useful in diagnosing, preventing, or treating IL-22-associated immune disorders, e.g., autoimmune disorders (e.g., arthritis).