Variable region gene of heavy/light chain of anti-human hepatoma monoclonal antibody HAb 18 and use thereof
US7638619B2 · kind B2 · utility
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2References
8Claims
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Inventors
Key dates
| Filing date | Mar 17, 2003 |
| Grant date | Dec 29, 2009 |
| Priority date | — |
| Expiry date | Jan 14, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/56
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the anti-human hepatocarcinoma McAb HAb18 heavy chain and light chain variable region genes, the polypeptides encoded by the same, as well as to their use in the preparation of a medicament for diagnosing and treating tumors or inflammation diseases. Based on the heavy chain and light chain variable region genes, various novel small molecule genetic engineering antibodies, including single chain antibodies, chimeric antibodies, Fab antibodies and the like can be constructed and expressed for the diagnosis and treatment of hepatoma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.