Magneto-optic biosensor using bio-functionalized magnetized nanoparticles
US7639359B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 19, 2007 |
| Grant date | Dec 29, 2009 |
| Priority date | — |
| Expiry date | Apr 10, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2021/1727
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A biosensor utilizing bio-functionalized magnetic nanoparticles is provided. An external magnetic field is applied to a suspension of magnetic nanoparticles. A linearly polarized incident light is applied to the suspension of magnetic nanoparticles. A photocurrent from polarized light scattering by bio-functionalized magnetic nanoparticles in liquid is detected. The magneto-optic sensing technique is applied to a micro-fluidic channel for rapid and sensitive detection with a small sample amount, and subsequent magnetic separation for detoxification. This technique is used for the detection of Brownian relaxation with time sweep as well as frequency sweep. The magneto-optical sensor enables rapidly detecting changes in local dynamic properties of the magnetic nanoparticles in liquids and magnetic modulation of ferromagnetic particles in liquid provides increased signal sensitivity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.