Wound treatment utilizing collagenase and a phosphotidylcholine organogel

US7641900B2 · kind B2 · utility

Assignee

• Research Foundation for the State University of New York York · US

Inventors

• Harry Soroff · Northport, US
• Marcia Simon · Stony Brook, US
• Thomas Fallon · West Chicago, US
• Peter Fallon · East Moriches, US
• Gabriele Hatch · Setauket, US

Key dates

• Filing date: Mar 30, 2005
• Grant date: Jan 5, 2010
• Expiry date: May 16, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/4886
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The effect of the action of collagenase in treating lesions containing collagen or mixed fibrin clots (e.g., burns or ulcers) is improved by applying collagenase to the wound in combination with an organogel and a phosphatidylcholine, of which lecithin is a readily available source, particularly when the collagenase is first mixed and stored with that choline and an organic solvent and is subsequently mixed with a second individually stored formulation comprising a gel-forming agent and water, the two formulations individually having satisfactory shelf lives and the resultant mixture being applied to the lesion promptly after being formed.