Multiple-valent opsonophagocytic assay selection panel arrays and uses therefor

US7642068B2 · kind B2 · utility

Assignee

• The United States of America as represtented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention · US

Inventors

• Sandra Steiner · Atlanta, US
• Patricia F. Holder · Mableton, US
• George M. Carlone · Stone Mountain, US
• Gowrisankar Rajam · Tucker, US

Key dates

• Filing date: Apr 21, 2006
• Grant date: Jan 5, 2010
• Expiry date: Apr 21, 2026

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/52
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

This application discloses a multivalent opsonophagocytosis assay that does not rely on counting of bacterial colonies to determine bacteria viability following opsonophagocytosis. Instead, the method uses a metabolic colorimetric indicator to determine if viable bacteria are present. Also disclosed are arrays that can be used to determine the viability of bacteria following opsonophagocytosis.