Compounds and compositions as protein kinase inhibitors

US7642255B2 · kind B2 · utility

Assignee

• IRM Inc. · BM

Inventors

• Taebo Sim · San Diego, US
• Hyun Soo Lee · San Diego, US
• Pingda Ren · San Diego, US
• Qiang Ding · San Diego, US
• Yi Liu · San Diego, US
• Bing Li · Towaco, US
• Lintong Li · San Diego, US
• Xia Wang · San Diego, US
• Tetsuo Uno · San Diego, US
• Guobao Zhang · San Diego, US
• Nathanael S. Gray · Boston, US
• Shuli You · Shanghai, CN

Key dates

• Filing date: Apr 8, 2008
• Grant date: Jan 5, 2010
• Expiry date: Apr 8, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases.