Inhibitors of acyl glucosaminyl inositol amidase and methods of use
US7642280B2 · kind B2 · utility
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3Claims
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Key dates
| Filing date | Apr 8, 2002 |
| Grant date | Jan 5, 2010 |
| Priority date | — |
| Expiry date | Apr 5, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides compounds with activity as inhibitors of acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived S-conjugate amides. Certain of the invention compounds are naturally occurring compounds obtained from marine sponges and other organisms. The invention further provides methods for using the compounds to inhibit virulence and reduce antibiotic resistance of mycothiol-producing bacteria.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.