Hydroxyapatite grafted fumarate based macromers for biodegradable composites
US7642300B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Jun 29, 2004 |
| Grant date | Jan 5, 2010 |
| Priority date | — |
| Expiry date | Apr 19, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61F2310/00293
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A composition is disclosed which comprises (i) a macromer prepared by reacting an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.