Polycyclic pyrazines as potassium ion channel modulators

US7642354B2 · kind B2 · utility

Assignee

• Icagen, LLC · US

Inventors

• Xiaodong Wang · Zhejiang, CN
• Kerry L. Spear · Oakland, US
• Alan Bradley Fulp · Fuquay-Varina, US
• Darrick Seconi · Cary, US
• Takeshi Suzuki · Ibaraki, JP
• Takahiro Ishii · Tokyo, JP
• Ayako Moritomo · Tokyo, JP

Key dates

• Filing date: Apr 13, 2005
• Grant date: Jan 5, 2010
• Expiry date: Oct 18, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides a genus of polycyclic pyrazines of formula (I):wherein A and B are independently substituted or unsubstituted 5- or 6- membered heterocycloalkyl, or substituted or unsubstituted 5- or 6- membered heteroaryl, W1 isW2is —CH═, —NH—, —N═, —S—, or —O—; Z1 isZ2 is —CH═, —NH—, —N═, —S—, or —O—; Y is a bond, —CH═N—NH—, —NH—CH2, or —NR5—; s and t are independently integers from 1 to 4; and the substituents R1, R2A, R2B and R3 are as defined in the specification for compounds of formula (I). The polycyclic pyrazine compounds are useful as modulators of potassium ion channels in both therapeutic and diagnostic methods.