Diabetes model animal
US7642401B2 · kind B2 · utility
0Cited by
2References
4Claims
0Family size
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Key dates
| Filing date | Aug 1, 2005 |
| Grant date | Jan 5, 2010 |
| Priority date | — |
| Expiry date | Feb 14, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/042
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
We prepared a transgene comprising human HB-EGF precursor cDNA, as a diphtheria toxin receptor gene, at the downstream of an insulin promoter, and introduced this transgene into a mouse fertilized egg, to produce a transgenic mouse of the present invention. In this mouse, human HB-EGF precursors are expressed specifically in islet beta cells, and by injection of diphtheria toxin, islet beta cells are selectively destroyed, resulting in that the mouse shows diabetes two or three days after the injection. This mouse can be utilized in screening and development of new medicines and therapy protocols for diabetes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.