Method for the detection of chromosomal aneuploidies
US7645576B2 · kind B2 · utility
238Cited by
2References
30Claims
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Key dates
| Filing date | Mar 17, 2006 |
| Grant date | Jan 12, 2010 |
| Priority date | — |
| Expiry date | Aug 13, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The non-invasive detection of fetal chromosomal aneuploidies is demonstrated. Alleles of fetal RNA-SNPs present in a biological sample (e.g. maternal blood) containing fetal RNA are detected and quantified in order to determine the ratio of the alleles. This ratio is compared to a standard control consisting of euploid fetuses. Deviation of allele ratio indicates the presence of chromosomal aneuploidy.
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