Mandelic acid derivatives and their use as thrombin inhibitors

US7645751B2 · kind B2 · utility

Assignee

• AstraZeneca

Inventor

• Tord Inghardt · Gately Drive, SE

Key dates

• Filing date: May 4, 2007
• Grant date: Jan 12, 2010
• Expiry date: May 4, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is provided a compound of formula (I) wherein Ra, R1, R2, Y and R3 have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g., thrombosis) or as anticoagulants.