8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical composition

US7645763B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Frank Himmelsbach · Mittelbiberach, DE
• Elke Langkopf · Biberach an der Riß, DE
• Matthias Eckhardt · Hannover, DE
• Mohammad Tadayyon · Hertford, GB
• Leo Thomas · Biberach, DE

Key dates

• Filing date: Feb 22, 2005
• Grant date: Jan 12, 2010
• Expiry date: Oct 11, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to substituted xanthines of general formulawherein R1 and R2 are defined as in the claims, the tautomers, the stereoisomers, the mixtures thereof, and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).