Production of polyketides and other natural products
US7645768B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 16, 2007 |
| Grant date | Jan 12, 2010 |
| Priority date | — |
| Expiry date | Jul 16, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/188
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.