Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof

US7645878B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Donald Bankston · Dracut, US
• Dhanaphalan Nagarathnam · Bethany, US
• Davoud Asgari · Wilmington, US
• Jianxing Shao · Acton, US
• Xiao-Gao Liu · Beijing, CN
• Uday Khire · Hamden, US
• Chunguang Wang · Hamden, US
• Barry Hart · Palo Alto, US
• Stephen Boyer · Fairfield, US
• Olaf Weber · Wülfrath, DE
• Mark Lynch · Madison, US

Key dates

• Filing date: Sep 24, 2002
• Grant date: Jan 12, 2010
• Expiry date: Mar 11, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.