Scoring estrogen and progesterone receptors expression based on image analysis
US7646905B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 16, 2003 |
| Grant date | Jan 12, 2010 |
| Priority date | — |
| Expiry date | Dec 11, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T7/0012
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
A method of scoring Oestrogen and Progesterone Receptors expression (ER and PR) from histological images determines the percentage of brown image blob area in total blob area and derives percentage thresholds to quantify scoring. Brown blob area proportion is then compared with the thresholds to provide a first contribution to scoring of ER or PR. The number of relatively dark pixels is then counted, pixel number thresholds are determined to quantify scoring, and the number of relatively dark pixels is compared with the thresholds to provide a second contribution scoring of ER or PR. The two contributions are then added to provide an overall scoring in the range 0 to 8 which may be taken as a final score or it may be scaled to a conventional range 0 to 3.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.