Mannose-6-phosphonate compounds for the treatment of inflammatory diseases
US7648966B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 20, 2004 |
| Grant date | Jan 19, 2010 |
| Priority date | — |
| Expiry date | Jun 9, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H11/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel phosphotetrahydropyran compounds that mimic mannose-6-phosphate but that are more resistant to phosphatases and mannosidases, and pharmaceutical compositions thereof, are disclosed. These compounds and compositions inhibit T lymphocyte migration from blood to tissues or to other extravascular sites. By inhibiting such migration, these compounds are useful for treating diseases or disorders that are mediated at least in part by such T lymphocyte migration. Such diseases and disorders include rheumatoid arthritis, multiple sclerosis, acute disseminated encephalomyelitis, psoriasis, inflammatory bowel disease, T cell-mediated dermatitis, stromal keratitis, uveitis, thyroiditis, sialitis and type I diabetes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.