Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors

US7648986B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Dhanapalan Nagarathnam · Bethany, US
• Uday Khire · Hamden, US
• Davoud Asgari · Wilmington, US
• Jianxing Shao · Acton, US
• Xiao-Gao Liu · Beijing, CN
• Chunguang Wang · Hamden, US
• Barry Hart · Palo Alto, US
• Olaf Weber · Wülfrath, DE
• Mark Lynch · Madison, US
• Lei Zhang · Beijing, CN
• Lei Wang · Beijing, CN

Key dates

• Filing date: Apr 9, 2007
• Grant date: Jan 19, 2010
• Expiry date: Apr 9, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.