Saquinavir conjugates and antibodies useful in immunoassay

US7649085B2 · kind B2 · utility

Assignee

• Roche Diagnostics Operations, Inc. · US

Inventors

• Gerald Sigler · Carmel, US
• Raymond Hui · Indianapolis, US
• Ina Deras · San Diego, US
• Richard Root · Fishers, US
• Erasmus Huber · Garching bei München, DE
• Herbert von der Eltz · Spaichingen, DE

Key dates

• Filing date: May 26, 2006
• Grant date: Jan 19, 2010
• Expiry date: Jun 29, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K16/44
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.