Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
US7650243B2 · kind B2 · utility
25Cited by
26References
19Claims
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Key dates
| Filing date | Feb 14, 2007 |
| Grant date | Jan 19, 2010 |
| Priority date | — |
| Expiry date | Feb 14, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.