Patent · US Expired

Methods for enhancing antigen presentation

US7651857B2 · kind B2 · utility

0Cited by

7References

21Claims

0Family size

Assignee

The Mathilda and Terence Kennedy Institute of Rheumatology Trust · GB

Inventors

Brian Maurice John Foxwell · London, GB
Marc Feldmann · London, GB

Key dates

Filing date	Dec 21, 2001
Grant date	Jan 26, 2010
Priority date	—
Expiry date	Feb 3, 2022

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2501/998
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

We describe (1) a method of enhancing antigen presentation, comprising the step of supplying to an antigen presenting cell such as a dendritic cell, or precursor cell, an inhibitor of Toll-related receptor (TRR) signalling and (2) a method of inhibiting antigen presentation, comprising the step of supplying to an antigen presenting cell such as a dendritic cell, or precursor cell, an enhancer of Toll-related receptor (TRR) signalling. The inhibitor of TRR signalling may be a dominant negative mutant of MyD88, for example MyD881pr.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.