Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them
US7651997B2 · kind B2 · utility
7Cited by
9References
27Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 20, 2006 |
| Grant date | Jan 26, 2010 |
| Priority date | — |
| Expiry date | Jun 20, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents and for other purposes. Methods of making these analogs and methods of using them as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.