Nitrogen-substituted hexahydropyrazino[1,2-A]pyrimidine-4,7-dione derivatives, processes for their preparation and their use as medicaments

US7652007B2 · kind B2 · utility

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Stefanie Flohr · Basel, CH
• Siegfried Stengelin · Frankfurt am Main, DE
• Matthias Gossel · Frankfurt am Main, DE
• Thomas Klabunde · Frankfurt, DE
• Petra Stahl · Frankfurt, DE
• Pavel Safar · Tucson, US
• James Spoonamore · Tucson, US
• Martin Smrcina · Tucson, US
• Joseph T. Klein · Bound Brook, US
• Gregory H. Merriman · Somerville, US
• Brian K. Whiteley · Lebanon, US
• Carolina Lanter · Audubon, US
• Kenneth J. Bordeau · Myerstown, US
• Zhaoxia Yang · Belmont, US

Key dates

• Filing date: Feb 13, 2004
• Grant date: Jan 26, 2010
• Expiry date: Feb 26, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Nitrogen-substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives, processes for the preparation and their use as medicamentsThe invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof.Compounds of the formula Iin which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example as anorectic agents.