Patent · US Active

2-(R)-(4-fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-a]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide maleate and pharmaceutical compositions thereof

US7652012B2 · kind B2 · utility

0Cited by

46References

2Claims

0Family size

Assignee

Glaxo Group Limited · GB

Inventors

Giuseppe Alvaro · Stevenage, GB
Romano Di Fabio · Verona, IT
Maria Tranquillini · Verona, IT
Simone Spada · Verona, IT

Key dates

Filing date	Dec 11, 2006
Grant date	Jan 26, 2010
Priority date	—
Expiry date	Aug 15, 2027

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to piperidine derivatives of formula (I)specifically 2-(R)-(4-Fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-a]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide maleate and pharmaceutical compositions thereof, useful in the treatment of conditions mediated by tachykinins.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.