Compounds for the treatment of inflammatory disorders

US7652020B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Zhuyan Guo · Scotch Plains, US
• Peter Orth · New York, US
• Zhaoning Zhu · Plainsboro, US
• Robert Mazzola · Stewartsville, US
• Tin-Yau Chan · Edison, US
• Henry A. Vaccaro · South Plainfield, US
• Brian McKittrick · New Vernon, US
• Joseph A. Kozlowski · Princeton, US
• Brian J. Lavey · New Providence, US
• Guowei Zhou · Somerville, US
• Sunil Paliwal · Manalapan, US
• Shing-Chun Wong · Union, US
• Neng-Yang Shih · Lexington, US
• Pauline C. Ting · New Providence, US
• Kristin E. Rosner · Watertown, US
• Gerald W. Shipps, Jr. · Stoneham, US
• M. Arshad Siddiqui · Newton, US
• David B. Belanger · Cambridge, US
• Chaoyang Dai · Acton, US
• Dansu Li · New York, US
• Vinay M. Girijavallabhan · Woburn, US
• Janeta Popovici-Muller · Windham, US
• Wensheng Yu · Edison, US
• Lianyun Zhao · Burlington, US

Key dates

• Filing date: Jun 1, 2005
• Grant date: Jan 26, 2010
• Expiry date: Jun 1, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to compounds of the Formula (I):or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.