Phenylamino isothiazole carboxamidines as MEK inhibitors

US7652047B2 · kind B2 · utility

Assignee

• Ardea Biosciences, Inc · US

Inventors

• Hassan Abdellaoui · Aliso Viejo, US
• Robert Tam · Irvine, US
• Huanming Chen · Irvine, US
• Varaprasad Chamakura · Irvine, US
• Dinesh Barawkar · Lake Forest, US
• Andreas Maderna · Stony Point, US
• Zhi Hong · Chapel Hill, US
• Stanley Lang · Carlsbad, US

Key dates

• Filing date: Jul 11, 2008
• Grant date: Jan 26, 2010
• Expiry date: Jul 11, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention concerns compounds which inhibit MEK and which have activity as anti-neoplastic agents. These compounds include N-substituted-3-hydroxy-5-arylamino-isothiazole-4-carboxamidines. Also included are the tautomeric isothiazol-3(2H)-ones.