Tricyclic compounds useful as angiotensin II agonists

US7652054B2 · kind B2 · utility

Assignee

• VICORE PHARMA AB · SE

Inventors

• Mathias Alterman · Stockholm, SE
• Anders Hallberg · Stockholm, SE

Key dates

• Filing date: Nov 26, 2003
• Grant date: Jan 26, 2010
• Expiry date: Aug 12, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is provided compounds of formula (I), wherein X1, X2, X3, Y4, Y1, Y2, Y3, Y4, Z1, Z2, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.