Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
US7655225B2 · kind B2 · utility
1Cited by
184References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 19, 2008 |
| Grant date | Feb 2, 2010 |
| Priority date | — |
| Expiry date | Feb 19, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Ex vivo and in vivo methods of expanding a population of stem and/or progenitor cells, while at the same time reversibly inhibiting differentiation of the stem and/or progenitor cells by providing the stem and/or progenitor cells with an effective amount of at least one copper chelate, so as to maintain a free copper concentration available to said cells substantially unchanged, to thereby expand the population of said stem and/or progenitor cells, while at the same time reversibly inhibit differentiation of said stem and/or progenitor cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.