Patent · US Active

Anti-FC-gamma RIIB receptor antibody and uses therefor

US7655229B2 · kind B2 · utility

66Cited by

18References

40Claims

0Family size

Inventors

Andrew Chan · Menlo Park, US
Robert L. Shields · Cape Coral, US
Lawren Wu · Foster City, US

Key dates

Filing date	Apr 16, 2007
Grant date	Feb 2, 2010
Priority date	—
Expiry date	Apr 16, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/76
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present application describes antibodies that selectively bind human FcγRIIB, with little or no binding to other human FcγRs, e.g., human FcγRIIA. The invention also provides isolated bispecific antibodies comprising an antibody that selectively binds FcγRIIB, and a second antibody that specifically binds an activating receptor. Various uses, including therapeutic uses, for those antibodies are also described, including administration with anti-tumor antibodies and methods of inhibiting immune responses and suppressing histamine release.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.