Malaria vaccines

US7655247B2 · kind B2 · utility

Assignees

• Seattle Biomedical Research Institute · US
• The Government of the United States, as Respresented by the Secretary of the Army · US

Inventors

• Michal Fried · Seattle, US
• Patrick Duffy · Washington, US
• Susan Francis · Seattle, US
• Jason P. Wendler · Lincoln, US
• Theonest K. Mutabingwa · Muheza, TZ
• Andrew V. Oleinikov · Mill Creek, US

Key dates

• Filing date: Jan 3, 2008
• Grant date: Feb 2, 2010
• Expiry date: Jan 3, 2028

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides isolated placental P. falciparum polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-4 and 6-24, and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the placental P. falciparum polypeptides of the invention, compositions comprising one or more placental P. falciparum polypeptides of the invention, methods for inducing an immune response against the placental P. falciparum polypeptides, and methods for treating and diagnosing placental malaria.