Compositions and methods for systemic nucleic acid sequence delivery
US7655467B2 · kind B2 · utility
1Cited by
14References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 15, 2004 |
| Grant date | Feb 2, 2010 |
| Priority date | — |
| Expiry date | Nov 15, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides systemic nucleic acid sequence delivery without conventional systemic administration aids (SAAs). In certain embodiments, vascular permeability agents (VPAs), such as VEGF, are used in conjunction with nucleic acid viral vectors, such as adeno-associated virus (AAV). The present invention also provides methods of treating disease by co-administration of nucleic cid sequences encoding Igf-1 and dystrophin or dystrophin-like proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.