Luminescence characterization of quantum dots conjugated with biomarkers for early cancer detection

US7655479B2 · kind B2 · utility

Assignees

• University of South Florida · US
• H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC. · US
• The Regents of the University of California · US

Inventors

• Tatyana A. Zhukov · Lutz, US
• Sergei Ostapenko · Wesley Chapel, US
• Rebecca Sutphen · Tampa, US
• Johnathan M. Lancaster · Tampa, US
• Thomas A. Sellers · Tampa, US
• Jin Zhang · Santa Cruz, US

Key dates

• Filing date: Jun 30, 2005
• Grant date: Feb 2, 2010
• Expiry date: Nov 26, 2026

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/588
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Luminescent semiconductor quantum dots (QDs) conjugated with biomolecules to serve as sensitive probes for early detection of the cancer cells, specifically for ovarian cancer and lung cancer, which represents the most lethal malignancies. The luminescence characterization of the bin-conjugated QDs with cancer specific antigens using linkage molecules. Photo-enhancement is measured at various laser density power, temperatures and laser wavelengths.