Molecules with extended half-lives, compositions and uses thereof
US7658921B2 · kind B2 · utility
56Cited by
17References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 13, 2007 |
| Grant date | Feb 9, 2010 |
| Priority date | — |
| Expiry date | Jul 19, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides molecules, including IgGs, non-IgG immunoglobulin, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino acid modifications that increase the affinity of the constant domain or fragment for FcRn. Such proteins and molecules with increased half-lives have the advantage that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such molecules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.