Binding of pathological forms of prion proteins
US7659076B2 · kind B2 · utility
1Cited by
7References
7Claims
0Family size
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Key dates
| Filing date | Feb 28, 2003 |
| Grant date | Feb 9, 2010 |
| Priority date | — |
| Expiry date | Jan 2, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2828
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Infective aggregating forms of proteins such as PrP, amyloid, and tau are bound selectively in the presence of the normal form protein using a polyionic binding agent such as dextran sulphate or pentosan (anionic), or polyamine compounds such as pDADMAC (cationic) under selective binding conditions including the use of n-lauroylsarcosine at mildly alkaline pH, and may then be assayed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.