Rapamycin peptides conjugates: synthesis and uses thereof
US7659244B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 3, 2004 |
| Grant date | Feb 9, 2010 |
| Priority date | — |
| Expiry date | May 27, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/416
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to new rapamycin derivatives for the inhibition of cell proliferation. The compounds can advantageously target two proteins in dividing cells and interfere with cell cycle. There is thus provided derivatives of rapamycin in which the 42 position of rapamycin is linked to an amino acid or a peptide through a carbamate ester linkage. These rapamycin derivatives can be synthesized by reacting 42-O-(4-Nitrophenoxycarbonyl) rapamycin and an amino acid or a free amino peptide under basic conditions. These rapamycin derivatives can be used to inhibit the cell cycle and are therefore useful for treating cell proliferation disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.