Abuse-resistant amphetamine prodrugs

US7659253B2 · kind B2 · utility

Assignee

• Shire LLC · US

Inventors

• Travis Mickle · Four Corners, US
• Suma Krishnan · Belvedere, US
• Barney Bishop · Annandale, US
• Christopher Lauderback · Blacksburg, US
• James Scott Moncrief · Christiansburg, US
• Robert Oberlender · Blacksburg, US
• Thomas Piccariello · Blacksburg, US
• Bernhard J. Paul · Lexington, US
• Christopher A. Verbicky · Broadalbin, US

Key dates

• Filing date: Jun 2, 2008
• Grant date: Feb 9, 2010
• Expiry date: Jun 2, 2028

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/173845
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.