PH-sensitive polymeric micelles for drug delivery
US7659314B2 · kind B2 · utility
3Cited by
1References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 14, 2004 |
| Grant date | Feb 9, 2010 |
| Priority date | — |
| Expiry date | Aug 19, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08F8/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.