Patent · US Active

Imiquimod production process

US7659398B2 · kind B2 · utility

2Cited by

6References

18Claims

0Family size

Assignee

Chemagis Ltd. · IL

Inventors

Vladimir Naddaka · Netanya, IL
Shady Saeed · Haifa, IL
Stephen Cherkez · Ramat Gan, IL
Oded Arad · Rehovot, IL

Key dates

Filing date	Feb 14, 2007
Grant date	Feb 9, 2010
Priority date	—
Expiry date	Jun 29, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D471/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention provides a process for preparing highly pure 4-amino-1-isobutyl-1H-imidazo[4,5-c]quinoline (imiquimod). The process preferably includes heating 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline of formula (II) with ammonia in a polar aprotic solvent at relatively moderate pressure to produce imiquimod, and optionally purifying the imiquimod. The process of the present invention can produce highly pure imiquimod in high yield.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.