Process for preparing 4-pentafluorosulfanylbenzoylguanidines

US7659429B2 · kind B2 · utility

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Gerrit Schubert · Kelkheim, DE
• Heinz-Werner Kleemann · Bischofsheim, DE

Key dates

• Filing date: Oct 9, 2008
• Grant date: Feb 9, 2010
• Expiry date: Oct 9, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C381/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing 4-pentafluorosulfanylbenzoylguanidines of formula Iwherein R1 to R4 have the meanings indicated in the specification. The compounds of formula I are NHE1 inhibitors and can be employed, for example, for the treatment of cardiovascular disorders.